Decoding the Transcriptome of Sharks, Rays, and Chimaeras: Insights into Their Physiology, Morphology, Evolution, and Biomedical Applications

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Seixas, MJ (Autor) Outra; Domingues, RR (Autor) Outra; Agostinho Antunes (Autor) FCUP

Revista

Título: Fishes

Vol. 8

Página Final: 271

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00Y-DJF

DOI: 10.3390/fishes8050271

Abstract (EN): Chondrichthyes (including sharks, rays, and chimaeras) are a class of jawed cartilaginous fishes (with skeletons composed primarily of cartilage), with major relevance to the marine ecosystems and to humanity. However, cartilaginous fishes are facing various threatens, inflicting abrupt declines in their populations. Thus, critical assessment of available molecular genetic variation, particularly retrieved from Chondrichthyans' transcriptomic analyses, represents a major resource to foster genomics research in this ancient group of vertebrate species. Briefly, RNA-Seq involves the sequencing of RNA strands present on a target tissue, which can assist genome annotation and elucidate genetic features on species without a sequenced genome. The resulting information can unravel responses of an individual to environmental changes, evolutionary processes, and support the development of biomarkers. We scrutinized more than 800 RNA-Seq entries publicly available, and reviewed more than one decade of available transcriptomic knowledge in chondrichthyans. We conclude that chondrichthyans' transcriptomics is a subject in early development, since not all the potential of this technology has been fully explored, namely their use to prospectively preserve these endangered species. Yet, the transcriptomic database provided findings on the vertebrates' evolution, chondrichthyans' physiology, morphology, and their biomedical potential, a trend likely to expand further in the future.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22