COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Queiroga, FL (Autor) Outra; Pires, I (Autor) Outra; Parente, M (Autor) Outra; Gregorio, H (Autor) Outra; Lopes, C (Autor) ICBAS

Revista

Título: Veterinary Journal

Vol. 189

Páginas: 77-82

ISSN: 1090-0233

Editora: Elsevier

Indexação

ISI Web of Knowledge - 36 Citações

Scopus - 47 Citações

Outras Informações

ID Authenticus: P-002-Q0V

DOI: 10.1016/j.tvjl.2010.06.022

Abstract (EN): This study was designed to investigate the possible roles of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in canine mammary cancer angiogenesis. Immunohistochemistry was performed on 70 tumours (28 benign and 42 malignant) in order to detect COX-2 and VEGF expression. Microvessel density (MVD) was determined by CD31 immunolabelling to assess tumour angiogenesis. There was a significantly higher expression of COX-2 (P < 0.001), VEGF (P < 0.001) and MVD (P < 0.001) in malignant compared to benign tumours. In the malignant group, the MVD of COX-2 positive tumours was significantly higher than that of COX-2 negative tumours (P = 0.026). A similar association was observed for VEGF (P < 0.001) positive tumours. The results from this study suggested that over-expression of COX-2 and VEGF may contribute to increased angiogenesis and aggression in malignant tumours.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6