Population and mutation analysis of Y-STR loci in a sample from the city of Sao Paulo (Brazil)

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Soares Vieira, JA (Autor) Outra; Billerbeck, AEC (Autor) Outra; Iwamura, ESM (Autor) Outra; Mendonca, BB (Autor) Outra; Gusmao, L (Autor) Outra; Otto, PA (Autor) Outra

Revista

Título: Genetics and Molecular Biology

Vol. 31

Páginas: 651-U25

ISSN: 1415-4757

Editora: Sociedade Brasileira de Genetica

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-004-3AA

DOI: 10.1590/s1415-47572008000400009

Abstract (EN): The haplotypes of seven Y-chromosome STR loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) were determined in a sample of 634 healthy Brazilian males (190 adult individuals and 222 father-son pairs). The 412 adults were unrelated, and the 222 father-son pairs had their biological relationship confirmed using autosomal STRs (LR > 10,000). Among the 412 adults, a total of 264 different 7-loci haplotypes were identified, 210 of which were unique. The most frequent haplotype was detected in 31 instances, occurring with a frequency of 7.52%. The haplotype diversity index was calculated as 98.83%. Upon transmission of the 1,554 alleles, in 222 father-son pairs, six mutations were observed, with an average overall rate of 3.86 x 10(-3) per locus. A haplotype with a duplicated DYS389I locus, and another with duplicated DYS389I, DYS389II, and DYS439 loci were detected in both fathers and their respective sons.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12