Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Correia da Costa, JMC (Autor) Outra; Nuno Vale (Autor) FCUP; Gouveia, MJ (Autor) Outra; Botelho, MC (Autor) Outra; Sripa, B (Autor) Outra; Santos, LL (Autor) Outra; Santos, JH (Autor) Outra; Rinaldi, G (Autor) Outra; Brindley, PJ (Autor) Outra

Revista

Título: Frontiers in Genetics

Vol. 5

ISSN: 1664-8021

Editora: Frontiers Media

Indexação

ISI Web of Knowledge - 44 Citações

Scopus - 46 Citações

Outras Informações

ID Authenticus: P-00A-1EN

DOI: 10.3389/fgene.2014.00444

Abstract (EN): Infection with helminth parasites remains a persistent public health problem in developing countries. Three of these pathogens, the liver flukes Clonorchis sinensis, Opisthorchis viverrini and the blood fluke Schistosoma haematobium, are of particular concern due to their classification as Group 1 carcinogens: infection with these worms is carcinogenic. Using liquid chromatography-mass spectrometry (LC-MS/MS) approaches, we identified steroid hormone like (e.g., oxysterol-like, catechol estrogen quinone-like, etc.) metabolites and related DNA-adducts, apparently of parasite origin, in developmental stages including eggs of S. haematobium, in urine of people with urogenital schistosomiasis, and in the adult stage of O. viverrini. Since these kinds of sterol derivatives are metabolized to active quinones that can modify DNA, which in other contexts can lead to breast and other cancers, helminth parasite associated sterols might induce tumor-like phenotypes in the target cells susceptible to helminth parasite associated cancers, i.e., urothelial cells of the bladder in the case of urogenital schistosomiasis and the bile duct epithelia or cholangiocytes, in the case of O. viverrini and C. sinensis. Indeed we postulate that helminth induced cancers originate from parasite estrogen-host epithelial/urothelial cell chromosomal DNA adducts, and here we review recent findings that support this conjecture.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7