Assessment of Bonelike (R) graft with a resorbable matrix using an animal model

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Lobato, JV (Autor) Outra; Sooraj S Hussain (Autor) Outra; Botelho, CM (Autor) Outra; Mauricio, AC (Autor) ICBAS; Américo Afonso (Autor) FMDUP; Ali, N (Autor) Outra; Santos, JD (Autor) FEUP

Revista

Título: Thin Solid Films

Vol. 515

Páginas: 362-367

ISSN: 0040-6090

Editora: Elsevier

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 14 Citações

INSPEC

COMPENDEX

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia dos materiais

CORDIS: Ciências Tecnológicas > Tecnologia > Tecnologia médica > Materiais biomédicos ; Ciências Tecnológicas > Engenharia > Engenharia biomédica

Outras Informações

ID Authenticus: P-004-H5H

DOI: 10.1016/j.tsf.2005.12.153

Abstract (EN): Synthetic bone grafts have been developed to provide an alternative to autografts and allografts. Bonelike((R)) is a patented synthetic osteoconductive bone graft that mimics the mineral composition of natural bone, In the present preliminary animal studies a user-firiendly version of synthetic bone graft Bonelike((R)) have been developed by using a resorbable matrix, Floseal((R)), as a vehicle and raloxifene hydrochloride as a therapeutic molecule, that is known to decrease osteoclast activity and therefore enhanced bone formation. From histological and scanning electron microscopy evaluations, the use of Bonelike((R)) associated with Floseal((R)) and raloxifene hydrochloride showed that new bone was rapidly apposed on implanted granules and also that the presence of the matrix and therapeutic molecule does not alter the proven highly osteoconductivity properties of Bonelike((R)). Therefore, this association may be one step-forward for the clinical applications of Bonelike((R)) scaffolds since it is much more easy-to-handle when compared to granular materials.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6