From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2021

Autores

Pinto, MMM (Autor) Outra; Palmeira, A (Autor) Outra; Carla Fernandes (Autor) FFUP; Resende, DISP (Autor) Outra; Emilia Sousa (Autor) FFUP; Honorina Cidade (Autor) FFUP; Tiritan M.E. (Autor) FFUP; Marta Correia da Silva (Autor) FFUP; Cravo, S (Autor) Outra

Revista

Título: Molecules

Vol. 26 Nº 17

Página Final: 431

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 60 Citações

Scopus - 67 Citações

Outras Informações

ID Authenticus: P-00T-E9S

DOI: 10.3390/molecules26020431

Abstract (EN): This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacological activities, formulation and analytical applications. Although her group activity has been spread over several chemical families with relevance in Medicinal Chemistry, the main focus of the investigation and research has been in the xanthone family. Xanthone derivatives have a variety of activities with great potential for therapeutic applications due to their versatile framework. The group has contributed with several libraries of xanthones derivatives, with a variety of activities such as antitumor, anticoagulant, antiplatelet, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective, antioxidant, and multidrug resistance reversal effects. Besides therapeutic applications, our group has also developed xanthone derivatives with analytical applications as chiral selectors for liquid chromatography and for maritime application as antifouling agents for marine paints. Chemically, it has been challenging to afford green chemistry methods and achieve enantiomeric purity of chiral derivatives. In this review, the structures of the most significant compounds will be presented.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 43