Paediatric dilated cardiomyopathy: clinical profile and outcome. The experience of a tertiary centre for paediatric cardiology

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Joana Miranda (Autor) FMUP; Costa, L (Autor) Outra; Rodrigues, E (Autor) Outra; Teles, EL (Autor) Outra; Baptista, MJ (Autor) Outra; Areias JC (Autor) FMUP

Revista

Título: Cardiology in the Young

Vol. 25

Páginas: 333-337

ISSN: 1047-9511

Editora: Cambridge University Press

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 16 Citações

Outras Informações

ID Authenticus: P-00A-7JM

DOI: 10.1017/s1047951113002369

Abstract (EN): Dilated cardiomyopathy is the most common form of cardiomyopathy in the paediatric population and an important cause of heart transplantation in children. The clinical profile and course of dilated cardiomyopathy in children have been poorly characterised. A retrospective review of 61 patients (37 female; 24 male) diagnosed with dilated cardiomyopathy from January, 2005 to June, 2012 at a single institution was performed. The median age at diagnosis was 15 months. Heart failure was present in 83.6% of patients and 44.3% required intensive care. The most prevalent causes were idiopathic (47.5%), viral myocarditis (18.0%) and inherited metabolic diseases (11.5%). In viral myocarditis, Parvovirus B19 was the most common identified agent, in concurrence with the increasing incidence documented recently. Inherited metabolic diseases were responsible for 11.5% of dilated cardiomyopathy cases compared with the 4-6% described in the literature, which reinforces the importance of considering this aetiology in differential diagnosis of paediatric dilated cardiomyopathy. The overall mortality rate was 16.1% and five patients underwent heart transplantation. In our series, age at diagnosis and aetiology were the most important prognosis factors. We report no mortality in the five patients who underwent heart transplantation, after 2 years of follow-up.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5