Body weight changes in patients with type 2 diabetes and a recent acute coronary syndrome: an analysis from the EXAMINE trial

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Ferreira, JP (Autor) FMUP; Rossignol, P (Autor) Outra; Bakris, G (Autor) Outra; Mehta, C (Autor) Outra; White, WB (Autor) Outra; Zannad, F (Autor) Outra

Revista

Título: Cardiovascular Diabetology

Vol. 20

ISSN: 1475-2840

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00V-D1N

DOI: 10.1186/s12933-021-01382-8

Abstract (EN): Background Patients with type 2 diabetes (T2D) may experience frequent body weight changes over time. The prognostic impact of these weight changes (gains or losses) requires further study. Aims To study the associations between changes in body weight (intentional or unintentional) with subsequent outcomes. Methods The EXAMINE trial included 5380 patients with T2D and a recent acute coronary syndrome, who were randomized to alogliptin or placebo. Time-updated Cox models and mixed effects models were used to test the associations between changes in body weight and subsequent outcomes over a median follow-up of 1.6 (1.0-2.1) years. Results During the post-randomization follow-up period, 1044 patients (19.4%) experienced a weight loss >= 5% of baseline weight, 2677 (49.8%) had a stable weight, and 1659 (30.8%) had a >= 5 % weight gain. Patients with weight loss were more frequently women and had more co-morbid conditions. In contrast, patients who gained >= 5% weight were more frequently men with less co-morbid conditions. A weight loss >= 5% was independently associated with a higher risk of subsequent adverse outcomes, including all-cause mortality: adjusted HR (95% CI) = 1.79 (1.33-2.42), P < 0.001. Similar associations were found for cardiovascular mortality, the composite of cardiovascular mortality or heart failure hospitalization, and the primary outcome. A weight gain >= 5% was independently associated with an increase in the risk of subsequent cardiovascular mortality or heart failure hospitalization only: adjusted HR (95% CI) = 1.34 (1.02-1.76), P = 0.033. Conclusions In patients with T2D who had a recent ACS/MI, a >= 5% loss of body weight was associated with a higher risk of subsequent cardiovascular events and mortality.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8