Dynein prevents erroneous kinetochore-microtubule attachments in mitosis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Barisic, M (Autor) Outra; Helder Maiato (Autor) FMUP

Revista

Título: Cell Cycle

Vol. 14

Páginas: 3356-3361

ISSN: 1538-4101

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00K-8PZ

DOI: 10.1080/15384101.2015.1089369

Abstract (EN): Equal distribution of the genetic material during cell division relies on efficient congression of chromosomes to the metaphase plate. Prior to their alignment, the Dynein motor recruited to kinetochores transports a fraction of laterally-attached chromosomes along microtubules toward the spindle poles. By doing that, Dynein not only contributes to chromosome movements, but also prevents premature stabilization of end-on kinetochore-microtubule attachments. This is achieved by 2 parallel mechanisms: 1) Dynein-mediated poleward movement of chromosomes counteracts opposite polar-ejection forces (PEFs) on chromosome arms by the microtubule plus-end-directed motors chromokinesins. Otherwise, they could stabilize erroneous syntelic kinetochore-microtubule attachments and lead to the random ejection of chromosomes away from the spindle poles; and 2) By transporting chromosomes to the spindle poles, Dynein brings the former to the zone of highest Aurora A kinase activity, further destabilizing kinetochore-microtubule attachments. Thus, Dynein plays an important role in keeping chromosome segregation error-free by preventing premature stabilization of kinetochore-microtubule attachments near the spindle poles.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6