Carbamazepine-induced interstitial pneumonitis associated with pan-hypogammaglobulinemia

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Goncalves, D (Autor) FMUP; Moura, R (Autor) Outra; Ferraz, C (Autor) Outra; Vitor, AB (Autor) Outra; Vaz, L (Autor) Outra

Revista

Título: Respiratory Medicine Case Reports

Vol. 5

Páginas: 6-8

ISSN: 2213-0071

Editora: Elsevier

Indexação

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-008-490

DOI: 10.1016/j.rmedc.2011.12.001

Abstract (EN): Carbamazepine remains a first-line drug for treatment of epilepsy in children. A wide variety of side effects have been attributed to its use, including a mild involvement of the immune system, usually a transient decline in IgA. Pulmonary complications, including interstitial pneumonitis, were mainly described in adults, and are considered rare side effects. In this report we describe the first pediatric patient who developed a severe interstitial pneumonitis and a pan-hypogammaglobulinemia 2 months after starting carbamazepine. A gradual resolution of symptoms and complete immune recovery was observed after the drug withdrawal, but 6 months later our patient still has a marked reduction in lung volumes and decreased exercise tolerance. We suggest that immunoglobulins should be carefully examined after carbamazepine initiation, particularly if the patient develops any sign of immunosuppression. © 2012 Elsevier Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica