Pathophysiological Mechanisms of Chronic Venous Disease and Implications for Venoactive Drug Therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Mansilha A. (Autor) FMUP; Sousa, J (Autor) FMUP

Revista

Título: International Journal Of Molecular Sciences

Vol. 19

Página Final: 1669

ISSN: 1661-6596

Editora: MDPI

Indexação

ISI Web of Knowledge - 129 Citações

Scopus - 147 Citações

Outras Informações

ID Authenticus: P-00P-2Q7

DOI: 10.3390/ijms19061669

Abstract (EN): Chronic venous disease (CVD) is a common pathology, with significant physical and psychological impacts for patients and high economic costs for national healthcare systems. Throughout the last decades, several risk factors for this condition have been identified, but only recently, have the roles of inflammation and endothelial dysfunction been properly assessed. Although still incompletely understood, current knowledge of the pathophysiological mechanisms of CVD reveals several potential targets and strategies for therapeutic intervention, some of which are addressable by currently available venoactive drugs. The roles of these drugs in the clinical improvement of venous tone and contractility, reduction of edema and inflammation, as well as in improved microcirculation and venous ulcer healing have been studied extensively, with favorable results reported in the literature. Here, we aim to review these pathophysiological mechanisms and their implications regarding currently available venoactive drug therapies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 21