Arterial stiffness in children and adolescents with and without continuous insulin infusion

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

C Correia (Autor) FMUP; Moura, C (Autor) Outra; Mota, C (Autor) Outra; Santos Silva, R (Autor) FMUP; Carlos Areias, JC (Autor) Outra; Conceicao Calhau (Autor) FMUP; Fontoura M (Autor) FMUP

Revista

Título: Journal of Pediatric Endocrinology and Metabolism

Vol. 32 Nº 3

Páginas: 837-841

ISSN: 0334-018X

Editora: Walter De Gruyter

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00Q-S5T

DOI: 10.1515/jpem-2019-0102

Abstract (EN): Background: Arterial stiffness is a consequence of aging, but there are several diseases that contribute to this process. The evaluation of pulse wave velocity (PWV) allows a dynamic evaluation of vascular distensibility and the detection of atherosclerosis at an early stage. It was intended to evaluate the PWV in children and adolescents with type 1 diabetes mellitus (T1DM) and to compare their outcome according to the type of treatment used. Methods: Forty-eight patients were randomly selected. Inclusion criteria: T1DM, under intensive insulin therapy (multiple daily insulin administrations [MDI] or continuous insulin infusion system [CIIS]). Exclusion criteria: existence of another chronic pathology or microvascular complications. Echocardiography was performed and three measurements of PWV were done, with their mean calculated. Results: Most of the children and adolescents presented a PWV >= the 75th centile. There was a statistically significant difference for hemoglobin A(1c) (HbA(1c)) (7.8 in CIIS vs. 9 in MDI, p <0.05). There were not statistically significant differences in the PWV between the two groups. This can be attributed to the fact that children with CIIS are those who previously presented greater glycemic instability. There was a significant correlation between PWV and disease duration (Pearson's correlation coefficient [r] = 0.314, p = 0.036). Conclusions: This study showed that in children and adolescents with T1DM, there is an important prevalence of arterial stiffness, translated by an increase in PWV. This increase in PWV appears to exist even in very young children with little disease evolution time.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5