Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Ricardo Jorge Dinis Oliveira (Autor) FMUP

Revista

Título: Drug Metabolism Reviews

Vol. 49

Páginas: 84-91

ISSN: 0360-2532

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 47 Citações

Scopus - 48 Citações

Outras Informações

ID Authenticus: P-00M-HEQ

DOI: 10.1080/03602532.2016.1278228

Abstract (EN): Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)(2A) subtype receptors. During the last few years, psilocybin and psilocin have gained therapeutic relevance but considerable physiological variability between individuals that can influence dose-response and toxicological profile has been reported. This review aims to discuss metabolism of psilocybin and psilocin, by presenting all major and minor psychoactive metabolites. Psilocybin is primarily a pro-drug that is dephosphorylated by alkaline phosphatase to active metabolite psilocin. This last is then further metabolized, psilocin-O-glucuronide being the main urinary metabolite with clinical and forensic relevance in diagnosis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8