Tobacco smoking and intestinal metaplasia: Systematic review and meta-analysis identified

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Morais, S (Autor) Outra; Rodrigues, S (Autor) Outra; Amorim, L (Autor) Outra; peleteiro, b (Autor) FMUP; Lunet N (Autor) FMUP

Revista

Título: Digestive and Liver Disease

Vol. 46

Páginas: 1031-1037

ISSN: 1590-8658

Editora: Elsevier

Indexação

ISI Web of Knowledge - 21 Citações

Scopus - 22 Citações

Outras Informações

ID Authenticus: P-009-XP3

DOI: 10.1016/j.dld.2014.08.034

Abstract (EN): Background: The evaluation of specific risk factors for early endpoints in the gastric carcinogenesis pathway may further contribute to the understanding of gastric cancer aetiology. Aims: To quantify the relation between smoking and intestinal metaplasia through systematic review and meta-analysis. Methods: Articles providing data on the association between smoking and intestinal metaplasia were identified in PubMed (R), Scopus (R) and Web of Science (TM), searched until April 2014, and through backward citation tracking. Summary odds ratio estimates and 95% confidence intervals were computed using the DerSimonian and Laird method. Heterogeneity was quantitatively assessed using the I-2 statistic. Results: A total of 32 articles were included in this systematic review and 19 provided data for meta- analysis. Smoking was defined as ever vs. never (crude estimates, six studies, summary odds ratio = 1.54,95% confidence interval: 1.12-2.12, I-2 = 67.4%; adjusted estimates, seven studies, summary odds ratio = 1.26,95% confidence interval: 0.98-1.61, I-2 = 65.0%) and current vs. non-smokers (crude estimates, seven studies, summary odds ratio = 1.27, 95% confidence interval: 0.88-1.84, I-2 = 73.4%; adjusted estimates, two studies, summary odds ratio 1.49, 95% confidence interval: 0.99-2.25, I-2 = 0.0%). Conclusion: The weak and non-statistically significant association found through meta-analysis of the available evidence does not confirm smoking as an independent risk factor for intestinal metaplasia.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7