Neuro-COVID frequency and short-term outcome in the Northern Portuguese population

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Oliveira, V (Autor) Outra; Seabra, M (Autor) Outra; Rodrigues, R (Autor) Outra; Carvalho, V (Autor) Outra; Mendes, M (Autor) Outra; Pereira, D (Autor) Outra; Caldeiras, C (Autor) Outra; Martins, B (Autor) Outra; Silva, R (Autor) Outra; Azevedo, A (Autor) Outra; Lima, MJ (Autor) Outra; Monteiro, C (Autor) Outra; Varela, R (Autor) Outra; Malheiro, S (Autor) Outra; Abreu, M (Autor) Outra; Elsa Azevedo (Autor) FMUP; Loureiro, JL (Autor) Outra; Cruz, VT (Autor) Outra; Silva, MR (Autor) Outra; Magalhaes, R (Autor) ICBAS; silva, mc (Autor) Outra; Maia, LF (Autor) Outra; Correia, M (Autor) Outra

Revista

Título: European Journal of Neurology

ISSN: 1351-5101

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 9 Citações

Outras Informações

ID Authenticus: P-00T-Z2V

DOI: 10.1111/ene.14874

Abstract (EN): Background and purpose: COVID-19-related acute neurological phenotypes are being increasingly recognised, with neurological complications reported in more than 30% of hospitalised patients. However, multicentric studies providing a population-based perspective are lacking. Methods: We conducted a retrospective multicentric study at five hospitals in Northern Portugal, representing 45.1% of all hospitalised patients in this region, between 1 March and 30 June 2020. Results: Among 1261 hospitalised COVID-19 patients, 457 (36.2%) presented neurological manifestations, corresponding to a rate of 357 per 1000 in the North Region. Patients with neurologic manifestations were younger (68.0 vs. 71.2 years, p = 0.002), and the most frequent neurological symptoms were headache (13.4%), delirium (10.1%), and impairment of consciousness (9.7%). Acute well-defined central nervous system (CNS) involvement was found in 19.1% of patients, corresponding to a rate of 217 per 1000 hospitalised patients in the whole region. Assuming that all patients with severe neurological events were hospitalised, we extrapolated our results to all COVID-19 patients in the region, estimating that 116 will have a severe neurological event, corresponding to a rate of nine per 1000 (95% CI = 7-11). Overall case fatality in patients presenting neurological manifestations was 19.8%, increasing to 32.6% among those with acute well-defined CNS involvement. Conclusions: We characterised the population of hospitalised COVID-19 patients in Northern Portugal and found that neurological symptoms are common and associated with a high degree of disability at discharge. CNS involvement with criteria for in-hospital admission was observed in a significant proportion of patients. This knowledge provides the tools for adequate health planning and for improving COVID-19 multidisciplinary patient care.

Idioma: Inglês

Tipo (Avaliação Docente): Divulgação

Nº de páginas: 9