Lymphangiogenesis: From the pig embryos to cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2008

Autores

Longatto Filho, A (Autor) Outra; Duarte, M (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Jornal Brasileiro de Patologia e Medicina Laboratorial

Vol. 44

Páginas: 215-220

ISSN: 1676-2444

Editora: Sociedade Brasileira de Patologia Clinica

Indexação

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-007-NQF

DOI: 10.1590/s1676-24442008000300010

Abstract (EN): The discovery and the comprehension of lymphatic vessels suffered several historical delays and setbacks. The inherent anatomical problems slowed down the precise identification of the lymphatic system during the development of medical science. Gasparo Aselli, an Italian surgeon and anatomist, was the first to describe the lymphatic vessels in 1627 (De Lacteibus sive Lacteis Venis). However, most original descriptions that report the morphology of the lymphatic system in different organisms were done during the 19th and the 20th centuries. The recent identification of specific lymphatic vasculature molecular markers allows a more accurate identification and characterization of the lymphatic system evolution in different organs, as well as its role in different pathological conditions, including cancer. This study summarizes the current understanding of lymphangiogenesis in tumour progression, as well as it presents a review of the promising data regarding the prognostic value of lymphatic density and the use of therapeutic lymphangiogenic molecules.

Idioma: Inglês

Tipo (Avaliação Docente): Científica