p40: A p63 Isoform Useful for Lung Cancer Diagnosis - A Review of the Physiological and Pathological Role of p63

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

Nobre, AR (Autor) Outra; Albergaria, A (Autor) FMUP; Fernando Schmitt (Autor) FMUP

Revista

Título: Acta Cytologica

Vol. 57

Páginas: 1-8

ISSN: 0001-5547

Editora: Karger

Indexação

ISI Web of Knowledge - 47 Citações

Scopus - 55 Citações

Outras Informações

ID Authenticus: P-002-1TQ

DOI: 10.1159/000345245

Abstract (EN): At present, p63, TTF-1, and Napsin-A are the main immunochemical markers used to distinguish squamous cell carcinoma (SCC) from lung adenocarcinoma (ADC). However, studies using antibodies against p63 have demonstrated false-positive results with positivity in some ADC. In contrast, the expression of one of the p63 isoforms (Delta Np63), detected by the antibody p40, is highly specific for SCC. Since most cases of lung cancer are diagnosed in small specimens (cytology/biopsies) and saving material for molecular analysis is mandatory, we recommended the use of p40 (in adjunct with TTF-1 and/or Napsin-A) as the best approach to discriminate SCC and lung ADC. In this paper, we review the physiological and pathological role of p63 isoforms as well as their use as diagnostic markers in lung SCC. Copyright (c) 2012 S. Karger AG, Basel

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8