Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Pinheiro, C (Autor) Outra; Reis, RM (Autor) Outra; Ricardo, S (Autor) Outra; Longatto, A (Autor) Outra; Fernando Schmitt (Autor) FMUP; Baltazar, F (Autor) Outra

Revista

Título: Journal of Biomedicine and Biotechnology

Vol. 2010 Nº 807084

Páginas: 1-7

ISSN: 1110-7243

Editora: HINDAWI PUBLISHING CORPORATION

Indexação

ISI Web of Knowledge - 143 Citações

Scopus - 150 Citações

Outras Informações

ID Authenticus: P-003-BJH

DOI: 10.1155/2010/427694

Abstract (EN): Monocarboxylate transporters (MCTs) are important cellular pH regulators in cancer cells; however, the value of MCT expression in cancer is still poorly understood. In the present study, we analysed MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as CD147 and CD44. MCT expression frequency was high and heterogeneous among the different tumours. Comparing with normal tissues, there was an increase in MCT1 and MCT4 expressions in breast carcinoma and a decrease in MCT4 plasma membrane expression in lung cancer. There were associations between CD147 and MCT1 expressions in ovarian cancer as well as between CD147 and MCT4 in both breast and lung cancers. CD44 was only associated with MCT1 plasma membrane expression in lung cancer. An important number of MCT1 positive cases are negative for both chaperones, suggesting that MCT plasma membrane expression in tumours may depend on a yet nonidentified regulatory protein.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7