Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Lukoyanov, NV (Autor) FMUP; Watanabe, H (Autor) Outra; Carvalho, LS (Autor) Outra; Kononenko, O (Autor) Outra; Sarkisyan, D (Autor) Outra; Zhang, ML (Autor) Outra; Andersen, MS (Autor) Outra; Lukoyanova, EA (Autor) Outra; Galatenko, V (Autor) Outra; Tonevitsky, A (Autor) Outra; Bazov, I (Autor) Outra; Iakovleva, T (Autor) Outra; Schouenborg, J (Autor) Outra; Bakalkin, G (Autor) Outra

Revista

Título: eLife

Vol. 10

ISSN: 2050-084X

Editora: eLife Sciences Publications

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00V-8TQ

DOI: 10.7554/elife.65247

Abstract (EN): Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expression patterns in the lumbar spinal cord. The injury-induced postural effects were abolished by hypophysectomy and were mimicked by transfusion of serum from animals with brain injury. Administration of the pituitary neurohormones beta-endorphin or Arg-vasopressin-induced side-specific hindlimb responses in naive animals, while antagonists of the opioid and vasopressin receptors blocked hindlimb postural asymmetry in rats with brain injury. Thus, in addition to the well-established involvement of motor pathways descending from the brain to spinal circuits, the side-specific humoral signaling may also add to postural and reflex asymmetries seen after brain injury.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 33