Follicular lesions with papillary nuclear characteristics: differences in chromatin detected by computerized image analysis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Coelho, BP (Autor) Outra; Valentim, FD (Autor) Outra; Miot, HA (Autor) Outra; Jaune, DTA (Autor) Outra; Hayashi, CY (Autor) Outra; de Oliveira, CC (Autor) Outra; Marques, MD (Autor) Outra; Tagliarini, JV (Autor) Outra; Castilho, EC (Autor) Outra; Soares, P (Autor) FMUP; Mazeto, GMFD (Autor) Outra

Revista

Título: Archives of endocrinology and metabolism

Vol. 64

Páginas: 630-635

ISSN: 2359-3997

Editora: Segmento Farma Editores

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00S-X1T

DOI: 10.20945/2359-3997000000282

Abstract (EN): Objective: Follicular lesions of the thyroid with papillary carcinoma nuclear characteristics are classified as infiltrative follicularvariant of papillary thyroid carcinoma-FVPTC (IFVPTC), encapsulated/ well demarcated FVPTC with tumour capsular invasion (IEFVPTC), and the newly described category "non-invasive follicularthyroid neoplasm with papillary-like nuclear features" (NIFTP) formerly known as non-invasive encapsulated FVPTC.This study evaluated whether computerized image analysis can detect nuclear differences between these three tumour subtypes. Materials and methods: Slides with histological material from 15 cases of NIFTP and 33 cases of FVPTC subtypes (22 IEFVPTC, and 11 IFVPTC) were analyzed using the Image J image processing program.Tumour cells were compared for both nuclear morphometry and chromatin textural characteristics. Hestia:, Nuclei from NIFTP and IFVPTC tumours differed in terms of chromatin textural features (grey intensity): mean (92.37 +/- 21.01 vs 72.99 +/- 14.73, p = 0.02), median (84.93 +/- 21.17 vs 65.18 +/- 17.08, p = 0.02), standard deviation (47.77 +/- 9.55 vs 39.39 +/- 7.18; p = 0.02), and coefficient of variation of standard deviation (19.96 +/- 4.01 vs 24.75 +/- 3.31; p = 0.003). No differences were found in relation to IEFVPTC. Conclusion. Computerized image analysis revealed differences in nuclear texture between NIFTP and IFVPTC, but not for IEFVPTC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6