MicroRNAs in Lung Cancer Oncogenesis and Tumor Suppression: How it Can Improve the Clinical Practice?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Daniel Pozza (Autor) FMUP; De Mello, RA (Autor) Outra; Araujo, RLC (Autor) Outra; Velcheti, V (Autor) Outra

Revista

Título: Current Genomics

Vol. 21

Páginas: 372-381

ISSN: 1389-2029

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00S-JEP

DOI: 10.2174/1389202921999200630144712

Abstract (EN): Background: Lung cancer (LC) development is a process that depends on genetic mutations. The DNA methylation, an important epigenetic modification, is associated with the expression of noncoding RNAs, such as microRNAs. MicroRNAs are particularly essential for cell physiology, since they play a critical role in tumor suppressor gene activity. Furthermore, epigenetic disruptions are the primary event in cell modification, being related to tumorigenesis. In this context, microRNAs can be a useful tool in the LC suppression, consequently improving prognosis and predicting treatment. Conclusion: This manuscript reviews the main microRNAs involved in LC and its potential clinical applications to improve outcomes, such as survival and better quality of life.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10