Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Pereira, JA (Autor) Outra; Benninger, Y (Autor) Outra; Baumann, R (Autor) Outra; Goncalves, AF (Autor) Outra; Oezcelik, M (Autor) Outra; Thurnherr, T (Autor) Outra; Tricaud, N (Autor) Outra; Meijer, D (Autor) Outra; Faessler, R (Autor) Outra; Suter, U (Autor) Outra; Relvas, JB (Autor) Outra

Revista

Título: Journal of Cell Biology

Vol. 185

Páginas: 147-161

ISSN: 0021-9525

Editora: Rockefeller University Press

Indexação

ISI Web of Knowledge - 74 Citações

Scopus - 86 Citações

Outras Informações

ID Authenticus: P-003-KVS

DOI: 10.1083/jcb.200809008

Abstract (EN): During development, Schwann cells (SCs) interpret different extracellular cues to regulate their migration, proliferation, and the remarkable morphological changes associated with the sorting, ensheathment, and myelination of axons. Although interactions between extracellular matrix proteins and integrins are critical to some of these processes, the downstream signaling pathways they control are still poorly understood. Integrin-linked kinase (ILK) is a focal adhesion protein that associates with multiple binding partners to link integrins to the actin cytoskeleton and is thought to participate in integrin and growth factor-mediated signaling. Using SC-specific gene ablation, we report essential functions for ILK in radial sorting of axon bundles and in remyelination in the peripheral nervous system. Our in vivo and in vitro experiments show that ILK negatively regulates Rho/Rho kinase signaling to promote SC process extension and to initiate radial sorting. ILK also facilitates axon remyelination, likely by promoting the activation of downstream molecules such as AKT/protein kinase B.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15