Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Ferraz, R (Autor) Outra; Silva, D (Autor) Outra; Dias, AR (Autor) Outra; Dias, V (Autor) Outra; Santos, MM (Autor) FCUP; Pinheiro, L (Autor) Outra; Prudencio, C (Autor) Outra; Noronha, JP (Autor) Outra; Petrovski, Z (Autor) Outra; Branco, LC (Autor) Outra

Revista

Título: Pharmaceutics

Vol. 12

Página Final: 221

ISSN: 1999-4923

Editora: MDPI

Indexação

ISI Web of Knowledge - 56 Citações

Scopus - 61 Citações

Outras Informações

ID Authenticus: P-00R-VER

DOI: 10.3390/pharmaceutics12030221

Abstract (EN): The preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen] and amoxicillin [seco-Amx] hydrolysate derivatives and their in vitro antibacterial activity against sensitive and resistant Escherichia coli and Staphylococcus aureus strains is reported. Eleven hydrolyzed beta-lactam-OSILs were obtained after precipitation in moderate-to-high yields via the neutralization of the basic ammonia buffer of antibiotics with different cation hydroxide salts. The obtained minimum inhibitory concentration (MIC) data of the prepared compounds showed a relative decrease of the inhibitory concentrations (RDIC) in the order of 100 in the case of [C2OHMIM][seco-Pen] against sensitive S. aureus ATCC25923 and, most strikingly, higher than 1000 with [C(16)Pyr][seco-Amx] against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. These outstanding in vitro results showcase that a straightforward transformation of standard antibiotics into hydrolyzed organic salts can dramatically change the pharmaceutical activity of a drug, including giving rise to potent formulations of antibiotics against deadly bacteria strains.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 23