Metabolic Syndrome Is Associated With Impaired Diastolic Function Independently of MRI-Derived Myocardial Extracellular Volume: The MESA Study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Ladeiras-Lopes R (Autor) FMUP; Moreira, HT (Autor) Outra; Bettencourt, N (Autor) FMUP; Fontes-Carvalho R (Autor) FMUP; Sampaio, F (Autor) FMUP; Ambale Venkatesh, B (Autor) Outra; Wu, CL (Autor) Outra; Liu, K (Autor) Outra; Bertoni, AG (Autor) Outra; Ouyang, P (Autor) Outra; Bluemke, DA (Autor) Outra; Lima, JA (Autor) Outra

Revista

Título: Diabetes

Vol. 67

Páginas: 1007-1012

ISSN: 0012-1797

Editora: American Diabetes Association

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 26 Citações

Outras Informações

ID Authenticus: P-00N-WFJ

DOI: 10.2337/db17-1496

Abstract (EN): The relationship of metabolic syndrome (MetS) and insulin resistance (one of its key pathophysiological mediators) with diastolic dysfunction and myocardial fibrosis is not well understood. This study aimed to evaluate the association of MetS with diastolic function and myocardial extracellular matrix (ECM) using cardiac MRI (CMRI) in a large community-based population. This cross-sectional analysis included 1,582 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) with left ventricular ejection fraction >= 50% and no history of cardiac events. Diastolic function was assessed using tagged CMRI parameters including end-diastolic strain rate (EDSR) and strain relaxation index (SRI). ECM was evaluated using extracellular volume (ECV) quantification. Participants' mean age was 67.4 +/- 8.6 years, and 48.1% were males. MetS was present in 533 individuals (33.7%), and type 2 diabetes in 250 (15.8%). In the multivariable analyses, MetS (irrespective of the presence of type 2 diabetes) and higher insulin resistance were associated with impaired diastolic function (higher SRI and lower EDSR), independent of ECV. In conclusion, MetS, irrespective of the presence of type 2 diabetes, was independently associated with impaired diastole. These functional myocardial changes seem to result from intrinsic cardiomyocyte alterations, irrespective of the myocardial interstitium (including fibrosis).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6