Oral Lichen Planus in IBD Patients: A Paradoxical Adverse Effect of Anti-TNF-alpha Therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Andrade, P (Autor) Outra; Lopes, S (Autor) Outra; Albuquerque, A (Autor) Outra; Osorio, F (Autor) Outra; Pardal, J (Autor) Outra; Macedo G (Autor) FMUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: DIGESTIVE DISEASES AND SCIENCES

Vol. 60

Páginas: 2746-2749

ISSN: 0163-2116

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00G-3MJ

DOI: 10.1007/s10620-015-3680-2

Abstract (EN): Introduction and aims The efficacy of tumor necrosis factor alpha (TNF-alpha) inhibitors in the treatment of Inflammatory Bowel Disease (IBD) is well established. Many cutaneous and mucosal lesions have been described under anti-TNF-alpha therapy, some of them being considered as paradoxical. In this series we aimed to review the cases of oral lichen planus (OLP) in IBD patients under treatment with anti-TNF-alpha agents. Methods Histologic findings from oral lesions of IBD patients treated with anti-TNF were revised. Results Three female patients with IBD developed oral lichen planus (OLP) after starting anti-TNF-alpha therapy. Other etiologies were excluded. Conclusions In light of the increasing use of TNF-alpha inhibitors the occurrence of OLP is a potentially emerging side effect, thus we recommend a careful monitoring for oral manifestations in IBD patients treated with anti-TNF-alpha agents.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4