Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Lopes Marques, M (Autor) Outra; Ruivo, R (Autor) Outra; Fonseca, E (Autor) Outra; Teixeira, A (Autor) Outra; Filipe F C Castro (Autor) FCUP

Revista

Título: Molecular Phylogenetics and Evolution

Vol. 116

Páginas: 78-86

ISSN: 1055-7903

Editora: Elsevier

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 12 Citações

Outras Informações

ID Authenticus: P-00M-ZXX

DOI: 10.1016/j.ympev.2017.08.014

Abstract (EN): Gene duplication and loss are powerful drivers of evolutionary change. The role of loss in phenotypic diversification is notably illustrated by the variable enzymatic repertoire involved in vertebrate protein digestion. Among these we find the pepsin family of aspartic proteinases, including chymosin (Cmy). Previous studies demonstrated that Cmy, a neo-natal digestive pepsin, is inactivated in some primates, including humans. This pseudogenization event was hypothesized to result from the acquisition of maternal immune immunoglobulin G (IgG) transfer. By investigating 94 mammalian subgenomes we reveal an unprecedented level of Cmy erosion in placental mammals, with numerous independent events of gene loss taking place in Primates, Dermoptera, Rodentia, Cetacea and Perissodactyla. Our findings strongly suggest that the recurrent inactivation of Cmy correlates with the evolution of the passive transfer of IgG and uncovers a noteworthy case of evolutionary crosstalk between the digestive and the immune system, modulated by gene loss.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9