EGFR exon mutation distribution and outcome in non-small-cell lung cancer: a Portuguese retrospective study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

de Mello, RA (Autor) Outra; F.M. Andrade Pires (Autor) FEUP; Marques, DS (Autor) Outra; Oliveira, J (Autor) Outra; Rodrigues, A (Autor) Outra; Soares, M (Autor) Outra; Azevedo, I (Autor) Outra; Peixoto, A (Autor) Outra; Santos, C (Autor) Outra; Pinto, C (Autor) Outra; Hespanhol V (Autor) FMUP; Manuel R Teixeira (Autor) ICBAS; Amaro, T (Autor) Outra; Queiroga, H (Autor) FMUP; Araujo, A (Autor) Outra

Revista

Título: Tumor Biology

Vol. 33

Páginas: 2061-2068

ISSN: 1010-4283

Editora: SAGE

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 27 Citações

Outras Informações

ID Authenticus: P-002-31M

DOI: 10.1007/s13277-012-0465-5

Abstract (EN): Epidermal growth factor receptor (EGFR) mutations play a predictive role in advanced stages of non-small-cell lung cancer (NSCLC) patients. We conducted this study in order to assess EGFR status in a Portuguese population and its role in NSCLC patients' outcomes. Patients were submitted to EGFR assessment by high-resolution melting and/or direct sequencing. Kaplan-Meier curve was used to assess overall survival and progression-free survival (PFS). Two hundred forty eight out of 322 participants were assessed for EGFR status. Forty-two patients (16.9 %) presented EGFR-mutated status: one patient (2.4 %) presented exon 18; 21 patients (50 %), exon 19; one patient (2.4 %), exon 20; and 18 patients (45.2 %), exon 21 mutations, p < 0.001. PFS was not assessed (n.a.) for patient with exon 18 mutation, and for the other patients with mutations, it was 7 months (3.96-10.03) (exon 19), < 1 month (exon 20), and 7 months (0-14.2) (exon 21) (p = 0.027). Overall survival (OS) was 11 months (exon 18), 11 months (1-18) (exon 19), 1 month (exon 20), and 7.5 months (2-70) (exon 21) (p = n.a). This study suggests that the EGFR mutation is herein observed in a higher proportion than expected for a Caucasian population, and OS is a little less than that published in the literature.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8