Oncocytic Melanoma: A Study of a Rare Entity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Donner, LR (Autor) Outra; Maximo, V (Autor) FMUP

Revista

Título: American Journal of Dermatopathology

Vol. 40

Páginas: 854-856

ISSN: 0193-1091

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00P-SD7

DOI: 10.1097/dad.0000000000001183

Abstract (EN): The authors report the second case of oncocytic melanoma, one of the rarest known melanoma variants. The diagnosis was established by Fontana stain positivity, expression of S100 protein as well as gp100/HMB45, and demonstration of numerous mitochondria by ultrastructure. Because it is known that some oncocytic tumors of the thyroid gland and kidney contain point mutations and common deletions of mitochondrial DNA, the complete mitochondrial DNA of the reported oncocytic melanoma was also studied. It was normal except for 2 private separate point mutations, predicted to be not pathogenic, which do not seem to play any role in the tumor phenotype.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3