Modelling the suppression of autoimmunity after pathogen infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Oliveira, B.M.P.M. (Autor) FCNAUP; Trinchet, R (Autor) Outra; Otero Espinar, MV (Autor) Outra; Pinto, Aberto A. (Autor) FCUP; Burroughs, N (Autor) Outra

Revista

Título: Mathematical Methods in the Applied Sciences

Vol. 41

Páginas: 8565-8570

ISSN: 0170-4214

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 5 Citações

Classificação Científica

CORDIS: Ciências Físicas > Matemática

FOS: Ciências exactas e naturais > Matemática

Outras Informações

ID Authenticus: P-00P-Y6T

DOI: 10.1002/mma.4899

Abstract (EN): We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 (IL-2) secretion. We model the suppression of the autoimmune line of T cells after a different line of T cells responded to a pathogen infection. In this paper, we show that if the population of the pathogen responding line of T cells becomes large enough, the competition for IL-2 and the increase in the death rates may lead to a depletion in the concentration of autoimmune T cells. Provided this lasts for a sufficiently long time, the concentration of autoimmune T cells can be brought down to values inside the basin of attraction of the controlled state, and autoimmunity can be suppressed. Copyright © 2018 John Wiley & Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica