Gold nanoparticles for targeting varlitinib to human pancreatic cancer cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Sílvia Castro Coelho (Autor) FEUP; Daniel Pires Reis (Autor) Outra; Maria do Carmo Pereira (Autor) FEUP; Manuel A. N. Coelho (Autor) FEUP

Revista

Título: Pharmaceutics

Vol. 10 Nº 3

Páginas: 1-12

ISSN: 1999-4923

Editora: MDPI

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 8 Citações

Projetos Associados

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

NanoEFEct - Nanoparticle enhanced molecular Fluorescence-Endoscopy for detection of early stage colorectal adenocarcinoma

Outras Informações

ID Authenticus: P-00P-JCS

DOI: 10.3390/pharmaceutics10030091

Abstract (EN): Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spectroscopy. The drug release response shows an initial delay and a complete drug release after 72 h is detected. In vitro experiments with MIA PaCa-2 cells corroborate that PEGAuNPsVarl conjugates increase the varlitinib toxic effect at very low concentrations (IC50 = 80 nM) if compared with varlitinib alone (IC50 = 259 nM). Our results acknowledge a decrease of drug side effects in normal cells and an enhancement of drug efficacy against to the pancreatic cancer cells reported. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12