Preparation of chitosan-hydroxyapatite composite mono-fiber using coagulation method and their mechanical properties

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Okada, T (Autor) Outra; Nobunaga, Y (Autor) Outra; Konishi, T (Autor) Outra; Yoshioka, T (Autor) Outra; Hayakawa, S (Autor) Outra; Lopes, MA (Autor) FEUP; Miyazaki, T (Autor) Outra; Shirosaki, Y (Autor) Outra

Revista

Título: Carbohydrate Polymers

Vol. 175

Páginas: 355-360

ISSN: 0144-8617

Editora: Elsevier

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 17 Citações

Outras Informações

ID Authenticus: P-00N-3VK

DOI: 10.1016/j.carbpol.2017.07.072

Abstract (EN): Autograft has been carried out for anterior cruciate ligament (ACL) reconstruction surgery. However, it has negative aspect because patients lose their healthy ligaments from other part. We focus on a chitosan-hydroxyapatite (HAp) composite fiber as a scaffold of ligament regeneration. Chitosan- HAp composite fiber was made by using coagulation method. Chitosan-NaH2PO4 solution was coagulated with coagulation bath including calcium ion to get the mono-fiber and then treated with sodium hydroxide solution to form HAp in fiber matrix. The mechanical property of the fiber was improved by the stretching of the wet one because of the orientation of chitosan molecule and the interaction between chitosan and HAp. Maximum stress was improved with increasing of sodium dihydrogen phosphate until 0.03 M. The swelling ratio of the fiber was inhibited by composited with HAp. Additionally, bone-bonding ability was confirmed by SBF soaking tests.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6