Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Carvalho, IM (Autor) Outra; Coelho, PB (Autor) Outra; Paulo Costa (Autor) FFUP; Marques, CS (Autor) Outra; Oliveira, RS (Autor) Outra; Ferreira, DC (Autor) FFUP

Revista

Título: NeuroMolecular Medicine

Vol. 17

Páginas: 404-422

ISSN: 1535-1084

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00G-MCY

DOI: 10.1007/s12017-015-8369-3

Abstract (EN): The adult central nervous system is commonly known to have a very limited regenerative capacity. The presence of functional stem cells in the brain can therefore be seen as a paradox, since in other organs these are known to counterbalance cell loss derived from pathological conditions. This fact has therefore raised the possibility to stimulate neural stem cell differentiation and proliferation or survival by either stem cell replacement therapy or direct administration of neurotrophic factors or other proneurogenic molecules, which in turn has also originated regenerative medicine for the treatment of otherwise incurable neurodegenerative and neuropsychiatric disorders that take a huge toll on society. This may be facilitated by the fact that many of these disorders converge on similar pathophysiological pathways: excitotoxicity, oxidative stress, neuroinflammation, mitochondrial failure, excessive intracellular calcium and apoptosis. This review will therefore focus on the most promising achievements in promoting neuroprotection and neuroregeneration reported to date.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19