Dual/multitargeted xanthone derivatives for Alzheimer's disease: where do we stand?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Cruz, MI (Autor) Outra; Honorina Cidade (Autor) FFUP; Pinto, M (Autor) Outra

Revista

Título: Future Medicinal Chemistry

Vol. 9

Páginas: 1611-1630

ISSN: 1756-8919

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 23 Citações

Outras Informações

ID Authenticus: P-00N-28V

DOI: 10.4155/fmc-2017-0086

Abstract (EN): To date, the current therapy for Alzheimer's disease (AD) based on acetylcholinesterase inhibitors is only symptomatic, being its efficacy limited. Hence, the recent research has been focused in the development of different pharmacological approaches. Here we discuss the potential of xanthone derivatives as new anti-Alzheimer agents. The interference of xanthone derivatives with acetylcholinesterase and other molecular targets and cellular mechanisms associated with AD have been recently systematically reported. Therefore, we report xanthones with anticholinesterase, monoamine oxidase and amyloid beta aggregation inhibitory activities as well as antioxidant properties, emphasizing xanthone derivatives with dual/multitarget activity as potential agents to treat AD. We also propose the structural features for these activities that may guide the design of new, more effective xanthone derivatives.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20