Single Low-Dose Ionizing Radiation Induces Genotoxicity in Adult Zebrafish and its Non-Irradiated Progeny

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Lemos, J (Autor) Outra; Neuparth, T (Autor) Outra; Trigo, M (Autor) Outra; Costa, P (Autor) Outra; Vieira, D (Autor) Outra; Cunha, L (Autor) Outra; Ponte, F (Autor) Outra; Costa, PS (Autor) Outra; Metello, LF (Autor) Outra; Carvalho, AP (Autor) FCUP

Revista

Título: Bulletin of Environmental Contamination and Toxicology

Vol. 98

Páginas: 190-195

ISSN: 0007-4861

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 9 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00M-GM2

DOI: 10.1007/s00128-016-2006-1

Abstract (EN): This study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000 mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage. The level of DNA damage in irradiated parental fish increased in a radiation dose-dependent manner at day 1 post-irradiation, but returned to the control level thereafter. The level of DNA damage in the progeny was directly correlated with the parental irradiation dose. Results highlight the genotoxic risk of a single exposure to low-dose ionizing radiation in irradiated individuals and also in its non-irradiated progeny.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6