Exploratory Studies on the in Vitro Anti-inflammatory Potential of Two Herbal Teas (Annona muricata L. and Jasminum grandiflorum L.), and Relation with Their Phenolic Composition

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Oliveira, AP (Autor) Outra; Sa, I (Autor) Outra; David M Pereira (Autor) FFUP; Goncalves, RF (Autor) Outra; Paula B Andrade (Autor) FFUP; Patricia Valentao (Autor) FFUP

Revista

Título: Chemistry and Biodiversity

Vol. 14

Página Final: e1700002

ISSN: 1612-1872

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-00M-W74

DOI: 10.1002/cbdv.201700002

Abstract (EN): The need of new anti-inflammatory drugs has led to the search for safer and more potent molecules in distinct sources, such as natural products. This work aimed to explore the anti-inflammatory potential of aqueous extracts from two herbal teas (Annona muricata L. and Jasminum grandiflorum L.) in RAW 264.7 macrophages cells and in cell-free assays. Furthermore, the phenolic composition of both extracts and of their hydrolysates was characterized by HPLC-DAD, in order to establish possible relationships with the biological activity. In a general way, A. muricata displayed a stronger capacity to inhibit nitric oxide (NO) production and the activity of phospholipase A(2) (PLA(2)), displaying an IC50 value of 142 mu g/ml against this enzyme. A deeper look at phenolic compounds revealed that aglycones had more capacity to inhibit NO and PLA(2) than their corresponding glycosides, quercetin being clearly the most potent one (IC50 = 7.47 and 1.36 mu M, respectively). In addition, 5-O-caffeoylquinic acid, at 1.56 mu M, could also inhibit PLA(2) (ca. 35%). Our findings suggest that the consumption of both herbal teas may be a preventive approach to inflammatory disorders.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11