Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Carneiro F (Autor) FMUP; Oliveira C (Autor) FMUP; Suriano, G (Autor) Outra; Seruca, R (Autor) FMUP

Revista

Título: JOURNAL OF CLINICAL PATHOLOGY

Vol. 61

Páginas: 25-30

ISSN: 0021-9746

Indexação

ISI Web of Knowledge - 64 Citações

Scopus - 77 Citações

Outras Informações

ID Authenticus: P-004-3TQ

DOI: 10.1136/jcp.2006.043679

Abstract (EN): Gastric cancer is one of the major causes of cancer-related death worldwide. Familial clustering is observed in about 10% of cases; 1-3% of cases are hereditary. In the latter group, a syndrome which has been well characterised is hereditary diffuse gastric cancer; this is specifically associated with CDH1 (E-cadherin) germline mutations in about 30% of families. In this article, the state of the art of familial gastric cancer regarding the clinical, molecular and pathology features is reviewed, as well as the practical aspects for a correct diagnosis and clinical management.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6