The apelinergic system: a promising therapeutic target

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2010

Autores

Falcao Pires, I (Autor) FMUP; Ladeiras-Lopes R (Autor) FMUP; Leite-Moreira AF (Autor) FMUP

Revista

Título: Expert Opinion on Therapeutic Targets

Vol. 14 Nº 2

Páginas: 633-645

ISSN: 1472-8222

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 39 Citações

Scopus - 42 Citações

Outras Informações

ID Authenticus: P-003-629

DOI: 10.1517/14728221003752743

Abstract (EN): Importance of the field: Apelin is a bioactive peptide known as the ligand of the G-protein-coupled receptor APJ. In recent years, there has been a growing body of evidence regarding the importance of apelin and APJ in the pathophysiology of cardiovascular, metabolic and gastrointestinal diseases, brain signalling, HIV infection and tumor angiogenesis. Therefore, the apelinergic system is involved in the pathogenesis of several diseases that represent a major burden to our society. Areas covered in this review: The goal of this paper is to give an up-to-date review of existing information on apelin/APJ since the discovery of apelin in 1998, with particular focus on their involvement in the regulation of human body systems and potential therapeutic applications. What the reader will gain: An overview of the most important physiological functions of the apelinergic system and the diseases that may benefit in the future from its modulation as a therapeutic target. Take home message: Today, the established biological effects of apelin involve major cardiovascular actions, neoangiogenesis, immunologic modulation and insulinemia control as well as body fluid and glucose homeostasis. However, the physiological and pathophysiological role of endogenous apelin is still unsettled and a better and profound knowledge of this system in humans is necessary for the development of novel apelinergic-based therapeutic targets.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13