GABA DECREASES IN THE SPINAL-CORD DORSAL HORN AFTER PERIPHERAL NEURECTOMY

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 1993

Autores

Castro-Lopes J.M. (Autor) FMUP; Isaura Tavares (Autor) FMUP; COIMBRA, A (Autor) Outra

Revista

Título: Brain Research

Vol. 620

Páginas: 287-291

ISSN: 0006-8993

Editora: Elsevier

Indexação

ISI Web of Knowledge - 209 Citações

Scopus - 227 Citações

Outras Informações

ID Authenticus: P-001-MRK

DOI: 10.1016/0006-8993(93)90167-l

Abstract (EN): A significant fall in the number of GABA-immunoreactive cells in laminae I-III of the rat spinal cord occurred in the somatotopic area of projection of the sciatic nerve after nerve transection. The decrease started at 2 weeks post-neurectomy, and at 4 weeks ipsilateral mean cell numbers were approximately 72% of contralateral control values. Similarly, the concentration of GABA in spinal homogenates was significantly reduced 4 weeks post-neurectomy. These data, together with our recent finding of an increase in spinal GABA during chronic inflammation of the hindlimb, suggest that the level of GABA in the dorsal horn is regulated by the amount of primary afferent input.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5