Gastric cancer: adding glycosylation to the equation

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

Pinho, SS (Autor) Outra; Carvalho, S (Autor) Outra; Marcos Pinto, R (Autor) Outra; Magalhaes, A (Autor) Outra; Oliveira, C (Autor) Outra; Gu, J (Autor) Outra; Mario Dinis Ribeiro (Autor) FMUP; Carneiro F (Autor) FMUP; Seruca, R (Autor) FMUP; Celso Reis (Autor) ICBAS

Revista

Título: Trends in Molecular Medicine

Vol. 19

Páginas: 664-676

ISSN: 1471-4914

Editora: Elsevier

Indexação

ISI Web of Knowledge - 91 Citações

Scopus - 97 Citações

Outras Informações

ID Authenticus: P-006-JR6

DOI: 10.1016/j.molmed.2013

Abstract (EN): Gastric cancer has a high incidence and mortality, so there is a pressing need to understand the underlying molecular mechanisms in order to discover novel biomarkers. Glycosylation alterations are frequent during gastric carcinogenesis and cancer progression. This review describes the role of glycans from the initial steps of the carcinogenesis process, in which Helicobacter pylori adheres to host mucosa glycans and modulates the glycophenotype, as well as how glycans interfere with epithelial cell adhesion by modulating epithelial cadherin functionality in gastric cancer progression. Other mechanisms regulating gastric cancer malignant behavior are discussed, such as increased sialylation interfering with key signaling pathways and integrin glycosylation leading to an invasive phenotype. Applications of these glycosylation alterations in the clinical management of gastric cancer patients are discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13