E-Cadherin Glycosylation in Cancer

• Tipo: Capítulo ou Parte de Livro
• Data: 2015

Autores

Pinho, SS (Autor) Outra; Celso Reis (Autor) ICBAS

Livro

Título: Glycoscience: Biology and Medicine

Páginas: 977-982

ISBN: 9784431548416; 9784431548409

ISBN Eletrónico: 978-4-431-54841-6

Indexação

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00G-Q8F

DOI: 10.1007/978-4-431-54841-6_54

Abstract (EN): E-cadherin is an epithelial cell-cell adhesion glycoprotein playing key roles in cancer cell invasion and metastasis. Glycosylation modifications of E-cadherin have been described to be instrumental for its biological functions both in homeostasis and in cancer cell biology. Different glycan structures have been described to regulate E-cadherin expression through interfering with its basic mechanisms including E-cadherin-mediated cell-cell adhesion, E-cadherin cellular trafficking, and E-cadherin-dependent signaling pathways. These E-cadherin glycosylation modifications have impact in tumor development and progression, being attractive biomarkers in the clinical setting. © Springer Japan 2015.

Idioma: Inglês

Tipo (Avaliação Docente): Científica