HURTHLE-CELL LESIONS OF THE THYROID - A COMBINED STUDY USING TRANSMISSION ELECTRON-MICROSCOPY, SCANNING ELECTRON-MICROSCOPY, AND IMMUNOCYTOCHEMISTRY

• Tipo: Artigo em Revista Científica Internacional
• Data: 1985

Autores

NESLAND, JM (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP; HOLM, R (Autor) Outra; SAMBADE, MC (Autor) Outra; JOHANNESSEN, JV (Autor) Outra

Revista

Título: Ultrastructural Pathology

Vol. 8

Páginas: 269-290

ISSN: 0191-3123

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 65 Citações

Scopus - 55 Citações

Outras Informações

ID Authenticus: P-001-WM7

Abstract (EN): Hurthle cell transformation found in 2 nodular goiters, 2 cases of Hashimoto's thyroiditis, 4 follicular adenomas, 3 follicular carcinomas, 2 papillary carcinomas and 1 anaplastic carcinoma were studied by transmission electron microscopy, scanning electron microscopy and immunocytochemistry. Ultrastructural features of Hurthle cells were identical in non-neoplastic and neoplastic lesions. Cells crammed with mitochondria, showing abnormalities in size, shape and content were prominent in most cases. The presence of distinct smooth-surfaced cells interspersed with cells with many microvilli is almost a pathognomonic scanning electron microscopic feature of benign and malignant Hurthle cell lesions. Most Hurthle cells stained positively for thyroglobulin in all cases, but no immunoreactivity for CEA and calcitonin was found.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22