Expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) and type I Lewis antigens in cases with and without Helicobacter pylori colonization in metaplastic glands of the human stomach

• Tipo: Artigo em Revista Científica Internacional
• Data: 2002

Autores

Teixeira, A (Autor) Outra; David L (Autor) FMUP; Celso Reis (Autor) Outra; Costa, J (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP

Revista

Título: Journal of Pathology

Vol. 197

Páginas: 37-43

ISSN: 0022-3417

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 39 Citações

Scopus - 42 Citações

Outras Informações

ID Authenticus: P-000-PHP

DOI: 10.1002/path.1083

Abstract (EN): Helicobacter pylori (H. pylori) causes gastritis and intestinal metaplasia (IM) that may evolve to gastric carcinoma. Paradoxically, IM leads to clearing of H. pylori, except for some cases in which it persists in damaging the mucosa. The objective of this study was to compare the profile of mucins and type I Lewis antigens in IM cases with and without H. pylori. Gastric biopsies (n=32) were double-stained using immunohistochemistry (MUC1, MUC2, MUC5AC, MUC6, Lea, sialyl-Le(a), and Le(b)) and histochemistry for H. pylori. H. pylori was observed in association with IM in 4 of 22 biopsies with IM (complete IM - 6; incomplete IM - 16). The four biopsies with IM and H. pylori displayed a particular pattern of incomplete IM: expression of MUC1 and MUC5AC and little/no expression of MUC2. The 18 biopsies with IM and without H. pylori had high levels of MUC2 expression, regardless of the IM type. The pattern of expression of type I Lewis antigens was similar in IM, regardless of the presence or absence of H. pylori. It is concluded that H. pylori is able to colonize incomplete IM whenever it contains foci expressing MUC1 and MUC5AC and no MUC2, independently from Le(a), sialyl-Le(a) and Le(b). The results suggest, furthermore, that MUC2 expression affects the ability of H. pylori to colonize IM areas, regardless of the levels of expression of MUC1 and MUC5AC. Copyright (C) 2002 John Wiley 1 Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7