Geographic distribution of vacA allelic types of Helicobacter pylori

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

Van Doorn, LJ (Autor) Outra; Figueiredo C (Autor) Outra; Megraud, F (Autor) Outra; Pena, S (Autor) Outra; Midolo, P (Autor) Outra; De Magalhaes Queiroz, DM (Autor) Outra; Carneiro F (Autor) FMUP; Vanderborght, B (Autor) Outra; Pegado, MDGF (Autor) Outra; Sanna, R (Autor) Outra; De Boer, W (Autor) Outra; Schneeberger, PM (Autor) Outra; Correa, P (Autor) Outra; Ng, EKW (Autor) Outra; Atherton, J (Autor) Outra; Blaser, MJ (Autor) Outra; Quint, WGV (Autor) Outra

Revista

Título: Gastroenterology

Vol. 116

Páginas: 823-830

ISSN: 0016-5085

Editora: Elsevier

Indexação

ISI Web of Knowledge - 338 Citações

Scopus - 378 Citações

Outras Informações

ID Authenticus: P-001-4PB

DOI: 10.1016/s0016-5085(99)70065-x

Abstract (EN): Background & Aims: Distinct allelic types of Helicobacter pylori vacA have been defined, The geographic distribution of vacA alleles and cagA was assessed in this study. Methods: A total of 735 cultures from patients in 24 countries were analyzed by polymerase chain reaction and reverse hybridization on a line probe assay (LiPA), Results: In 124 (16.9%) of the 735 cultures, multiple vacA genotypes were detected, permitting analysis of 611 strains. In Europe, a distribution gradient of sl subtypes was observed. In northern and eastern Europe, 89% were subtype s1b. s1a and s1b were equally present in France and Italy, whereas in Spain and Portugal 89% of strains were subtype s1b. sla and s1b were approximately equally prevalent in North America, In Central and South America, virtually all s1 strains were subtype s1b. Subtype s1c was observed in 77% of the sl isolates from East Asia. m1 and m2a have equal presence, except on the Iberian peninsula and in Central and South America, where m1 (86.2%) is more prevalent than m2 (13.8%). Subtype m2b was found exclusively among East Asian s1c strains. In all parts of the world, vacA s1/cagA-positive genotypes were associated with peptic ulcer disease (P < 0.001), Conclusions: These data indicate a geographic distribution of H. pylori genotypes and aid in understanding the relationship of H. pylori with disease.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8