Helicobacter pylori genotypes may determine gastric histopathology

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Nogueira, C (Autor) Outra; Figueiredo C (Autor) Outra; Carneiro F (Autor) FMUP; Gomes AT (Autor) FMUP; Barreira, R (Autor) Outra; Figueira, P (Autor) Outra; Salgado, C (Autor) Outra; Belo, L (Autor) Outra; Peixoto, A (Autor) Outra; Bravo, JC (Autor) Outra; Bravo, LE (Autor) Outra; Realpe, JL (Autor) Outra; Plaisier, AP (Autor) Outra; Quint, WGV (Autor) Outra; Ruiz, B (Autor) Outra; Correa, P (Autor) Outra; van Doorn, LJ (Autor) Outra

Revista

Título: American Journal of Pathology

Vol. 158

Páginas: 647-654

ISSN: 0002-9440

Editora: Elsevier

Indexação

ISI Web of Knowledge - 132 Citações

Scopus - 164 Citações

Outras Informações

ID Authenticus: P-000-WE1

DOI: 10.1016/s0002-9440(10)64006-0

Abstract (EN): The outcome of Helicobacter pylori infection has been associated with specific virulence-associated bacterial genotypes, The present study aimed to investigate the gastric histopathology in Portuguese and Colombian patients infected with H, pylori and to assess its relationship with bacterial virulence-associated vacA, cagA, and iceA genotypes, A total of 370 patients from Protugal (n = 192) and Colombia(n = 178) were studied. Corpus and antrum biopsy specimens were collected from each individual. Histopathological features were recorded and graded according to the updated Sydney system. H, pylori vacA, cagA, and iceA genes were directly genotyped in the gastric biopsy specimens by polymerase chain reaction and reverse hybridization. Despite the significant differences between the Portuguese and Colombian patient groups, highly similar results were observed with respect to the relation between H. pylori genotypes and histopathology, n, pylori vacA s1, vacA ml,cagA + genotypes were significantly associated with a higher H. pylori density, higher degrees of lymphocytic and neutrophilic infiltrates, atrophy, the type of intestinal metaplasia, and presence of epithelial damage. The iceA1 genotype was only associated with epithelial damage in Portuguese patients. These findings show that distinct H, pylori genotypes are strongly associated with histopathological findings in the stomach, confirming their relevance for the development of H. pylori-associated gastric pathology.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8