Immunohistochemical analysis of urokinase plasminogen activator and its prognostic value in canine mammary tumours

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Santos, A (Autor) Outra; Lopes, C (Autor) Outra; Marques, RM (Autor) Outra; Amorim, I (Autor) Outra; Ribeiro, J (Autor) Outra; Frias, C (Autor) Outra; Corália Vicente (Autor) ICBAS; Gaertner, F (Autor) Outra; Augusto Matos (Autor) ICBAS

Revista

Título: Veterinary Journal

Vol. 189

Páginas: 43-48

ISSN: 1090-0233

Editora: Elsevier

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 13 Citações

Outras Informações

ID Authenticus: P-002-Q0T

DOI: 10.1016/j.tvjl.2010.05.023

Abstract (EN): Urokinase plasminogen activator (uPA) has been associated with aggressive behaviour and poor prognosis in human breast cancer, but there is no information on its expression in canine mammary tumours (CMT). uPA immunohistochemical expression was studied in 119 CMT (24 benign, 95 malignant) to investigate its relationship with clinical and histopathological parameters. Dogs with malignant mammary tumours (MMT) underwent a 2-year follow-up evaluation. MMT expressed significantly more uPA than benign tumours. In MMT, high uPA stromal expression was significantly associated with larger tumour size, high Ki-67 expression, invasive growth, high histological grade, regional lymph node metastases, development of distant metastases, and lower overall survival (OS) and disease-free survival (DFS). On the basis of these results, uPA could be considered a useful prognostic factor in dogs with MMT.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6