Prognostic factors for successful testicle spermatid recover

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

sousa, m (Autor) ICBAS; Fernandes, S (Autor) Outra; barros, a (Autor) FMUP

Revista

Título: Molecular and Cellular Endocrinology

Vol. 166

Páginas: 37-43

ISSN: 0303-7207

Editora: Elsevier

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 15 Citações

Outras Informações

ID Authenticus: P-000-Z8A

DOI: 10.1016/s0303-7207(00)00295-1

Abstract (EN): Men with non-obstructive azoospermia exhibit different histopathologic syndromes in the testicle biopsy, varying from aplasia, Sertoli cell only syndrome, maturation arrest and hypoplasia. The genetic basis of these syndromes is discussed. We present the diagnostic testicle biopsies performed on 160 consecutive non-obstructive azoospermic patients, and these results were correlated with the findings after multiple bilateral treatment testicle biopsy. Each syndrome had to be reevaluated as for the presence of at least one focus of spermatogenesis up to the primary spermatocyte, round spermatid, elongating spermatid, elongated spermatid, or spermatozoa stages. The clinical outcome using donor sperm-IVF, spermatid or sperm intracytoplasmic injection is thereafter presented. A new prognosis based on the findings of this large clinical series coupled to results obtained with Y chromosome molecular screening is offered. Alternative treatments to donor sperm for men without spermatids are discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7