LONG-TERM ALCOHOL-CONSUMPTION REDUCES THE NUMBER OF NEURONAL NUCLEAR-PORES - A MORPHOMETRIC STUDY UNDERTAKEN IN CA3 HIPPOCAMPAL PYRAMIDS OF RATS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1988

Autores

ANDRADE, JP (Autor) FMUP; CADETELEITE, A (Autor) Outra; PAULABARBOSA, MM (Autor) Outra; VOLK, B (Autor) Outra; TAVARES, MA (Autor) FMUP

Revista

Título: Alcoholism: Clinical and Experimental Research

Vol. 12

Páginas: 286-289

ISSN: 0145-6008

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 8 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

Outras Informações

ID Authenticus: P-001-TFG

DOI: 10.1111/j.1530-0277.1988.tb00196.x

Abstract (EN): A close relationship between the number of nuclear pores and the cellular protein synthesis activity is known to exist. Previous biochemical investigations lead to admit that the widespread neuronal alcohol-induced degenerative changes could depend on a decrease in the neuronal protein synthesis. The morphometric analysis made on the nuclear pore complexes of CA3 hippocampal pyramids of long-term alohol-fed rats fully supports this attractive hypothesis, since it has been found a marked reduction in the number of pores per unit surface area of nuclear membrane, together with a reduction in their total number per nucleus.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4