Increase of widespread A, B1 and D Escherichia coli clones producing a high diversity of CTX-M-types in a Portuguese hospital

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Carla Rodrigues (Autor) Outra; Elisabete Machado (Autor) Outra; Joao Pires (Autor) Outra; Helena Ramos (Autor) Outra; Angela Novais (Autor) Outra; Luisa Peixe (Autor) FFUP

Revista

Título: Future Microbiology

Vol. 10

Páginas: 1125-1131

ISSN: 1746-0913

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 14 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-00G-KFN

DOI: 10.2217/fmb.15.38

Abstract (EN): Aim: To characterize temporal shifts in extended-spectrum -lactamases (ESBLs) and clones of clinical Escherichia coli isolates. Materials & methods: All ESBL-producing E. coli isolates from a Portuguese hospital (n = 112; June 2006-June 2007 and January-December 2010) were characterized by identification of phylogenetic groups, ESBL-types and virulence genes, XbaI-PFGE and MLST. Results: We observed a substantial increase in widespread E. coli clones from phylogroups A, B1 and D (e.g., ST10, ST23, ST117, ST155, ST648) producing mainly CTX-M-1, -14, -32 or SHV-12, along with a decrease in the proportion of the predominant CTX-M-15-producing B2-ST131 clone. Conclusion: The amplification of diverse CTX-M-producing A, B1 and D clonal complexes, which have been long identified in Portuguese nonclinical settings, unveils a role for these reservoirs in the landscape of ESBL-producing E. coli in the clinical setting.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7