Role of Common bla(OXA-24/OXA-40)-Carrying Platforms and Plasmids in the Spread of OXA-24/OXA-40 among Acinetobacter Species Clinical Isolates

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Filipa Grosso (Autor) Outra; Sandra Quinteira (Autor) FCUP; Laurent Poirel (Autor) Outra; Angela Novais (Autor) Outra; Luisa Peixe (Autor) FFUP

Revista

Título: Antimicrobial Agents and Chemotherapy

Vol. 56

Páginas: 3969-3972

ISSN: 0066-4804

Editora: American Society for Microbiology

Indexação

ISI Web of Knowledge - 43 Citações

Scopus - 44 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-002-8GA

DOI: 10.1128/aac.06255-11

Abstract (EN): The spread of OXA-24/OXA-40 (OXA-24/40)-producing Acinetobacter spp. in the Iberian Peninsula has been strongly influenced by clonal expansion, but the role of horizontal gene transfer has scarcely been explored. bla(OXA-24/40)-carrying plasmids and genetic environments were characterized in representative (n = 15) Acinetobacter species clinical isolates (obtained between 2001 and 2007) by Acinetobacter baumannii PCR-based replicon typing, sequencing, hybridization, and restriction fragment length polymorphism. Besides the identification of bla(OXA-24/40) within the chromosomes of some isolates, the circulation of common bla(OXA-24/40)-carrying plasmids (30-kb repA_AB; 10-kb aci2) and genetic backbones among Acinetobacter spp. was demonstrated.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4