Lipid profile changes by high activity anti-retroviral therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Duro, M (Autor) Outra; Sarmento Castro, R (Autor) Outra; Almeida, C (Autor) Outra; Medeiros, R (Autor) ICBAS; Rebelo, I (Autor) FFUP

Revista

Título: Clinical Biochemistry

Vol. 46

Páginas: 740-744

ISSN: 0009-9120

Editora: Elsevier

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 15 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia médica

Outras Informações

ID Authenticus: P-005-084

DOI: 10.1016/j.clinbiochem.2012.12.017

Abstract (EN): Objective: Study of the lipid profile in patients infected with HIV treated with different combinations of high activity anti-retroviral therapy (HAART). Design and methods: A retrospective cohort study of the lipid profile in patients undergoing HAART. The study analyzes the evolution of concentrations of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDLc) and HDL-cholesterol (HDLc) in a period of at least 3 years of treatment. From a total of 750 clinical cases analyzed in Hospital Joaquim Urbano (Oporto, Portugal) 124 patients were selected for this study. Results: After 3 years of treatment, we observed the development of dyslipidaemia by increases in TG (17%), TC (29%) and LDLc (9%), particularly in patients treated with a combination of drugs which included protease inhibitors (PI). Moreover, the non-nucleoside reverse transcriptase inhibitors (NNRTI) were associated with better lipid profile. The increase of 46% in HDLc was the most surprising finding. Conclusions: The results indicate that patients with HAART have a more atherogenic lipidic profile with increased TC, LDLc and TG levels. Since the effectiveness of NNRTI is similar to that of PI, but with a smaller atherogenic profile, it should be the first choice drug to be selected in the HIV treatment.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5